Dr. David W. Meinke

TEACHING:

• BIOL 3024: Introductory Genetics - taught with Dr. Ron Van den Bussche,
  Department of Zoology. Offered: Fall, Spring, alternate summers
• BOT 5813: Plant Developmental Genetics Offered: Every 2-3 years.  

RESEARCH:

The purpose of my research is to identify large numbers of genes with essential functions during plant embryogenesis. My approach has been to isolate and characterize embryo-defective mutants of Arabidopsis thaliana. A large multinational effort is underway to identify every gene in this model plant. My laboratory continues to play an active role in this multinational Arabidopsis Genome Research Project.

For more information about my NSF 2010 project on essential genes, please visit  www.SeedGenes.org.

Publications:

Meinke DW, Sussex IM (1979) Embryo-lethal mutants of Arabidopsis thaliana: a model system for genetic analysis of plant embryo development. Devel Biol 72: 50-61

Meinke DW, Sussex IM (1979) Isolation and characterization of embryo-lethal mutants of Arabidopsis thaliana. Devel Biol 72: 62-72

Meinke DW, Chen J, Beachy RN (1981) Expression of storage-protein genes during soybean seed development. Planta 153: 130-139

Meinke DW (1982) Embryo-lethal mutants of Arabidopsis thaliana: evidence for gametophytic expression of the mutant genes. Theor Appl Genet 63: 381-386

Meinke DW (1985) Embryo-lethal mutants of Arabidopsis thaliana: analysis of mutants with a wide range of lethal phases. Theor Appl Genet 69: 543-552

Meinke D, Franzmann L, Baus A, Patton D, Weldon R, Heath JD, Monnot C (1985) Embryo-lethal mutants of Arabidopsis thaliana. In: Freeling M (ed) UCLA Symposia on Molecular and Cellular Biology, Vol 35, Plant Genetics. Alan Liss, New York , pp 129-146

Marsden MPF, Meinke DW (1985) Abnormal development of the suspensor in an embryo-lethal mutant of Arabidopsis thaliana. Amer J Bot 72: 1801-1812

Meinke DW, Baus AD (1985) Gametophytic expression in embryo-lethal mutants of Arabidopsis thaliana. In: Mulcahy D, Mulcahy GB, Ottaviano E (eds) Biotechnology and Ecology of Pollen. Springer-Verlag , New York , pp 15-20

Meinke DW (1986) Embryo-lethal mutants and the study of plant embryo development. Oxford Surv Plant Molec Cell Biol 3: 122-165

Baus AD, Franzmann L, Meinke DW (1986) Growth in vitro of arrested embryos from lethal mutants of Arabidopsis thaliana. Theor Appl Genet 72: 577-586

Heath JD, Weldon R, Monnot C, Meinke DW (1986) Analysis of storage proteins in normal and aborted seeds from embryo-lethal mutants of Arabidopsis thaliana. Planta 169: 304-312

Ladin BF, Tierney ML, Meinke DW, Hosangadi P, Veith M, Beachy RN (1987) Developmental regulation of B-conglycinin in soybean axes and cotyledons. Plant Physiol 84: 35-41

Patton DA, Meinke DW (1988) High-frequency plant regeneration from cultured cotyledons of Arabidopsis thaliana. Plant Cell Rep 7: 233-237

Meinke D, Patton D, Shellhammer J, Reynolds-Duffer A, Franzmann L, Schneider T, Robinson K (1989) Developmental and molecular genetics of embryogenesis in Arabidopsis thaliana. In: Goldberg R (ed) UCLA Symposia on Molecular and Cellular Biology, Vol 92, The Molecular Basis of Plant Development. Alan Liss, New York, pp 121-132

Schneider T, Dinkins R, Robinson K, Shellhammer J, Meinke DW (1989) An embryo-lethal mutant of Arabidopsis thaliana is a biotin auxotroph. Devel Biol 131: 161-167

Franzmann L, Patton DA, Meinke DW (1989) In vitro morphogenesis of arrested embryos from lethal mutants of Arabidopsis thaliana. Theor Appl Genet 77: 609-616

Patton DA, Meinke DW (1990) Ultrastructure of arrested embryos from lethal mutants of Arabidopsis thaliana. Amer J Bot 77: 653-661

Shellhammer J, Meinke DW (1990) Arrested embryos from the bio1 auxotroph of Arabidopsis contain reduced levels of biotin. Plant Physiol 93: 1162-1167

Meinke DW (1991) Genetic analysis of plant development. In: Steward FC, Bidwell RGS (eds) Plant Physiology, Vol. 10, Growth and Development. Academic Press, NY, pp 437-490

Meinke DW (1991) Perspectives on genetic analysis of plant embryogenesis. Plant Cell 3: 857-866.

Errampalli D, Patton D, Castle L, Mickelson L, Hansen K, Schnall J, Feldmann K, Meinke D (1991) Embryonic lethals and T-DNA insertional mutagenesis in Arabidopsis. Plant Cell 3: 149-157

Patton DA, Franzmann LH, Meinke DW (1991) Mapping genes essential for embryo development in Arabidopsis thaliana. Mol Gen Genet 227: 337-347

Meinke DW (1991) Embryonic mutants of Arabidopsis thaliana. Devel Genet 12: 382-392

Meinke DW (1992) A homoeotic mutant of Arabidopsis thaliana with leafy cotyledons. Science 258: 1647-1650

Castle LA, Meinke DW (1993) Embryo-defective mutants as tools to study essential functions and regulatory processes in plant embryo development. Semin Devel Biol 4: 31-39

Meinke DW (1993) The emergence of plant developmental genetics. Semin Devel Biol 4: 1-2

Meinke DW (ed) (1993) Seminars in Developmental Biology, Vol 4, Plant Developmental Genetics. Saunders Publications, New York.

Yeung EC, Meinke DW (1993) Embryogenesis in plants: development of the suspensor. Plant Cell 5: 1371-1381

Castle LA, Errampalli D, Atherton TL, Franzmann LH, Yoon EH, Meinke DW (1993) Genetic and molecular characterization of embryonic mutants identified following seed transformation in Arabidopsis. Mol Gen Genet 241: 504-514

Meinke DW (1994) Diversity of embryonic mutants identified following Agrobacterium-mediated seed transformation in Arabidopsis thaliana. In: Coruzzi G, Puigdomenech P (eds) NATO ASI, Vol H 81, Molecular Genetic Analysis of Plant Development and Metabolism. Springer-Verlag, New York, pp 105-115

Castle LA, Meinke DW (1994) A FUSCA gene of Arabidopsis encodes a novel protein essential for plant development. Plant Cell 6: 25-41

Meinke DW, Franzmann LH, Nickle TC, Yeung EC (1994) Leafy cotyledon mutants of Arabidopsis. Plant Cell 6: 1049-1064

Meinke DW (1994) Seed development in Arabidopsis. In: Meyerowitz EM, Somerville CR (eds) Arabidopsis thaliana. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York, pp 253-295

Vernon DM, Meinke DW (1994) Embryogenic transformation of the suspensor in twin, a polyembryonic mutant of Arabidopsis. Devel Biol 165: 566-573

Schwartz BW, Yeung EC, Meinke DW (1994) Disruption of morphogenesis and transformation of the suspensor in abnormal suspensor mutants of Arabidopsis. Development 120: 3235-3245

Franzmann LH, Yoon ES, Meinke DW (1995) Saturating the genetic map of Arabidopsis thaliana with embryonic mutations. Plant J 7: 341-350

Meinke DW (1995) Molecular genetics of plant embryogenesis. Ann Rev Plant Physiol Plant Mol Biol 46: 369-394

Vernon DM, Meinke DW (1995) Late embryo-defective mutants of Arabidopsis. Devel Genet 16: 311-320

Meinke DW (1996) Embryo-defective mutants of Arabidopsis: cellular functions of disrupted genes and developmental significance of mutant phenotypes. In: Wang T, Cuming A (eds) Embryogenesis: The Generation of a Plant.  Bios Scientific Publishers, pp 35-50

Meinke DW (ed) (1996) The Multinational Coordinated Arabidopsis thaliana Genome Research Project, Progress Report, Year 5. NSF Publication 96-43

Schwartz BW, Vernon DM, Meinke DW (1997) Development of the suspensor: differentiation, communication, and programmed cell death during plant embryogenesis. In: Larkins BA, Vasil IK (eds) Advances in Cellular and Molecular Biology of Plants, Vol 4, Cellular and Molecular Biology of Plant Seed Development. Kluwer Academic Publishers, The Netherlands, pp 53-72

Meinke D, Koornneef M (1997) Community standards for Arabidopsis genetics. Plant J 12: 247-253

Meinke DW (ed) (1997) The Multinational Coordinated Arabidopsis thaliana Genome Research Project, Progress Report, Year 6. NSF Publication 97-131

Patton DA, Schetter AL, Franzmann LH, Nelson K, Ward ER, Meinke DW (1998) An embryo-defective mutant of Arabidopsis disrupted in the final step of biotin synthesis. Plant Physiol 116: 935-946

Nickle TC, Meinke DW (1998) A cytokinesis-defective mutant of Arabidopsis (cyt1) characterized by embryonic lethality, incomplete cell walls, and excessive callose. Plant J 15: 321-332

Liu CM, Meinke DW (1998) The titan mutants of Arabidopsis are disrupted in mitosis and cell cycle control during seed development. Plant J 16: 21-31

Meinke DW, Cherry JM, Dean C, Rounsley SD, Koornneef M (1998) Arabidopsis thaliana: a model plant for genome analysis. Science 282: 662-682

Meinke D, Tanksley S (2000)  The maturation and specialization of plant genomics.  Curr Opinion Plant Biol 3: 95-96

McElver J, Patton D, Rumbaugh M, Liu C-M, Yang LJ, Meinke D (2000) The TITAN5 gene of Arabidopsis encodes a protein related to the ADP ribosylation factor family of GTP binding proteins.  Plant Cell 12: 1379-1392.

Meinke D, Tzafrir I (2000)  Arabidopsis thaliana multinational genome research project.  Nature 408: Poster Supplement.  

Huala E, Dickerman AW, Garcia-Hernandez M, Weems D, Reiser L, LaFond F, Hanley D, Kiphart D, Zhuang M, Huang W, Mueller LA, Bhattacharyya D, Bhaya D, Sobral BW, Beavis W, Meinke DW, Town CD, Somerville C, Rhee SY. (2001)  The arabidopsis information resource (TAIR): a comprehensive database and web-based information retrieval, analysis, and visualization system for a model plant.  Nucleic Acids Res. 29: 102-105.

Lukowitz W, Nickle TC, Meinke DW, Last RL, Conklin PL, Somerville C.  (2001) Arabidopsis cyt1 mutants are deficient in a mannose-1-phosphate guanosyltransferase and point to a requirement of N-linked glycosylation for cellulose biosynthesis.  Proc. Natl. Acad. Sci. USA 98: 2262-2267.    

Schomburg FM, Patton DA, Meinke DW, Amasino RM. (2001)  FPA, a gene involved in floral induction in Arabidopsis, encodes a protein containing RNA-recognition motifs.  Plant Cell 13: 1427-1436.

Meinke DW (2001)  Genetics of seed development.  In: Brenner S, Miller J (eds) Encyclopedia of Genetics.  Academic Press, NY, pp. 1780-1782. 

McElver J, Tzafrir, I, Aux, G, Rogers R, Ashby C, Smith K, Thomas C, Schetter A, Zhou Q, Cushman MA, Tossberg J, Nickle T, Levin J, Law M, Meinke D, Patton D.  (2001) Insertional mutagenesis of genes required for seed development in Arabidopsis thaliana.  Genetics 159: 1751-1763. 

Tzafrir I, McElver JA, Liu CM, Yang LJ, Wu JQ, Martinez A, Patton DA, Meinke DW.  (2002) Diversity of TITAN functions in Arabidopsis seed development.  Plant Physiol. 128: 38-51. 

Liu CM, McElver J, Tzafrir I, Joosen R, Wittich P, Patton D, Van Lammeren AAM, Meinke D. (2002)  Condensin and cohesin knockouts in Arabidopsis exhibit a titan seed phenotype. Plant J. 29: 405-415.

Golden TA, Schauer SE, Lang JD, Pien S, Mushegian AR, Grossniklaus U, Meinke DW, Ray A (2002)  SHORT INTEGUMENTS/SUSPENSOR1/CARPEL FACTORY, a dicer homolog, is a maternal effect gene required for embryo development in Arabidopsis.  Plant Physiol. 130: 808-822.   

Schauer SE, Jacobsen SE, Meinke DW, Ray A (2002)  DICER-LIKE1: Blind men and elephants in Arabidopsis development.  Trends Plant Science 7: 487-491. 

Tzafrir I, Dickerman A, Brazhnik O, Nguyen Q, McElver J, Frye C, Patton D, Meinke D (2003).  The Arabidopsis SeedGenes Project.  Nucleic Acids Res. 31: 90-93. 

Meinke D, Meinke L, Showalter T, Schissel A, Mueller L, Tzafrir I (2003).  A sequence-based map of Arabidopsis genes with mutant phenotypes.  Plant Physiol. 131: 409-418. 

Meinke D, Scholl R (2003).  The preservation of plant genetic resources. Experiences with Arabidopsis.  Plant Physiol. 133: 1046-1050.